ODCs

Click node...

3 OMIM references -
4 associated genes
12 signs/symptoms

COMMON GENES: 1
COMMON SIGNS: 6

1 OMIM reference -
1 associated gene
10 signs/symptoms

Juvenile amyotrophic lateral sclerosis

Infantile-onset ascending hereditary spastic paralysis

Citations in the biomedical literature:

Juvenile amyotrophic lateral sclerosis		Infantile-onset ascending hereditary spastic paralysis
	Synonym(s): - JALS - Juvenile Charcot disease - Juvenile Lou Gehrig disease		Synonym(s): - IAHSP

	Classification (Orphanet): - Rare genetic disease - Rare neurologic disease		Classification (Orphanet): - Rare genetic disease - Rare neurologic disease

	Classification (ICD10): - Diseases of the nervous system -		Classification (ICD10): - Diseases of the nervous system -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: adult Type of inheritance: autosomal recessive		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: adult Type of inheritance: autosomal recessive

	External references: 3 OMIM references - No MeSH references		External references: 1 OMIM reference - No MeSH references


COMMON SIGNS	- Autosomal recessive inheritance - Elocution disorders / dysarthria / dysphonia - Hypereflexia - Hypertonia / spasticity / rigidity / stiffness - Pseudobulbar signs / spasmodic laugh and cry - Pyramidal syndrome

Juvenile amyotrophic lateral sclerosis		Infantile-onset ascending hereditary spastic paralysis
	Very frequent - Abnormal EMG / electromyogram / electropmyography - Abnormal gait - Motor deficit / trouble Frequent - Muscle hypotrophy / atrophy / dystrophy / agenesis / amyotrophy Occasional - Bladder and ureter anomalies - Sensitive trouble / deficit		Very frequent - Feeding disorder / dysphagia / swallowing / sucking disorder / esophageal dyskinesia - Hemiplegia / diplegia / hemiparesia / limb palsy - Speech troubles / aphasia / dysphasia / echolalia / mutism / logorrhea / dysprosodia Frequent - Abnormal eye movements / oculomotor disorder